International Journal of Rheumatology / 2013 / Article / Fig 5

Research Article

Possible Involvement of Foxp3+ Regulatory T Cells in the Development of Immune-Mediated Pancreatitis in MRL/Mp Mice Treated with Polyinosinic:Polycytidylic Acid

Figure 5

Representative immunostaining of Foxp3 in the pancreases (a) and the ratios of Foxp3/mono (Foxp3-positive cells/infiltrated mononuclear cells) in the pancreases (b) of poly I:C-treated MRL/Mp mice at the age of 18–20 weeks, poly I:C-treated BALB/c mice at the age of 18 weeks, and poly I:C-treated C57BL/6 mice at the age of 18 weeks. In MRL/Mp and C57BL/6 mice, abundant infiltration of Foxp3-positive cells was found among the lymphoid infiltrates in the pancreas but not in BALB/c mice. The Foxp3/mono ratios in MRL/Mp mice were significantly increased compared with BALB/c and C57BL/6 mice. ×100 magnification (large panel), ×400(inset). Data are expressed as ; .
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(a)
367325.fig.005b
(b)

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