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International Journal of Rheumatology
Volume 2013, Article ID 498581, 4 pages
Clinical Study

Anti-CCP Antibodies Are Not Associated with Familial Mediterranean Fever in Childhood

1Department of Pediatric, Istanbul Training and Research Hospital, Istanbul, Turkey
2Department of Biochemistry, Istanbul Training and Research Hospital, 34080 Istanbul, Turkey
3Department of Pediatric, Mustafa Kemal University Medical Faculty, 31000 Antakya, Turkey
4Department of Biochemistry, Giresun University Medical Faculty, 28000 Giresun, Turkey
5Department of Pediatric Rheumatology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey

Received 26 March 2013; Revised 16 June 2013; Accepted 7 August 2013

Academic Editor: Luis R. Espinoza

Copyright © 2013 Hatice Onur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Anticyclic citrullinated peptide antibodies (anti-CCP) testing is useful in the diagnosis of rheumatoid arthritis (RA) with high specificity. Arthritis is a very common clinical manifestation in children with familial Mediterranean fever (FMF). The aim of the study was to show the presence of anti-CCP antibodies in child individuals diagnosed with FMF. Material and Methods. The study groups comprised one hundred and twenty-six patients (126) diagnosed with FMF (female/male ( ): 66/60) and 50 healthy controls (female/male ( ): 25/25). Clinical and laboratory assessments of the FMF patients were performed during attack-free periods. Erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), fibrinogen, and anti-CCP antibody levels were measured. Results. Anti-CCP was negative in healthy controls and also in all FMF patients. There was not a significant difference in anti-CCP between the patient and the control groups. Our study has shown that anti-CCP was correlated moderately with age ( ; ), duration of illness ( ; ), and colchicine therapy ( ; ). Conclusion. Our data show that anti-CCP antibodies are not associated with FMF. Anti-CCP does not have a priority for identifying FMF arthritis from the other inflammatory arthritis.