Circulating Levels of Soluble Receptor Activator of NF-κB Ligand and Matrix Metalloproteinase 3 (and Their Antagonists) in Asian Indian Patients with Ankylosing Spondylitis

Table 1

Serum level of soluble receptor activator of NF-κB ligand (sRANKL), osteoprotegerin (OPG), matrix metalloproteinase 3 (MMP-3), and tissue inhibitor of metalloproteinase 1 (TIMP-1) in patients of ankylosing spondylitis versus controls.

	Ankylosing spondylitis (𝑛=85)	Controls (𝑛=20)	P
OPG pg/ml mean ± SD	649.7±286.8	389.3±244.8	<0.001
sRANKL pg/ml mean ± SD^a	349.2±872.0	554.7±1850.1	0.50
MMP-3 ng/ml mean ± SD	91.4±84.7	55.9±37.1	0.006
TIMP-1 ng/ml mean ± SD	520.6±450.7	296.5±114.2	0.001

asRANKL was above the lowest detectable limit in only one-fourth of the samples (done in 55 patients and 20 controls). In others the lowest detectable limit by kit (32.25 pg/ml) was taken to represent the value of the sample.