Hyperuricemia and Incident Cardiovascular Disease and Noncardiac Vascular Events in Patients with Rheumatoid Arthritis
Table 1
Characteristics of 813 patients with rheumatoid arthritis (RA) and 813 subjects without RA (non-RA).
RA ()
Non-RA ()
value
Age at incidence/index, years, mean ± SD
55.9 ± 15.7
55.9 ± 15.7
0.99
Sex, female, (%)
556 (68%)
556 (68%)
1.0
Race
0.023
White
761 (93.6%)
771 (94.8%)
0.10 (or white versus nonwhite)
American Indian/Alaska native
3 (0.4%)
1 (0.1%)
Asian
21 (2.6%)
14 (1.7%)
Black or African American
5 (0.6%)
12 (1.5%)
Native Hawaiian or other Pacific Islander
4 (0.5%)
0 (0%)
More than 1 race
11 (1.4%)
3 (0.4%)
Unknown
8 (1.0%)
12 (1.5%)
Length of follow-up, years, mean ± SD
9.6 ± 6.9
10.9 ± 7.2
—
Smoking status at incidence/index, (%)
Never
364 (45%)
435 (54%)
0.002
Current
178 (22%)
144 (18%)
Former
271 (33%)
234 (29%)
Body mass index at incidence/index, mean ± SD
27.8 ± 6.2
27.8 ± 7.8
0.74
Diabetes mellitus at incidence/index, (%)
79 (10%)
67 (8%)
0.30
Hypertension at incidence/index, (%)
307 (38%)
275 (34%)
0.10
Dyslipidemia at incidence/index, (%)
444 (55%)
391 (48%)
0.008
eGFR < 60 mL/min/1.73 m2 at incidence/index, (%)
74 (9%)
74 (9%)
1.0
Alcoholism at incidence/index, (%)
56 (7%)
55 (7%)
0.92
Low-dose aspirin at incidence/index, (%)
130 (16%)
135 (17%)
0.74
CVD at incidence/index, (%)
95 (12%)
99 (12%)
0.76
Serum uric acid at incidence/index date*, mg/dL
()
()
Mean ± SD
5.1 ± 2.6
5.2 ± 1.5
0.011
Median, IQR
4.8 (3.7, 5.9)
5.0 (4.1, 6.1)
Total number of uric acid tests performed**
5231
3258
—
Number of tests per patient, mean (SD)
8.4 (11.7)
6.9 (8.9)
—
Rate of uric acid tests per person-year of follow-up
0.77 per 1 py
0.50 per 1 py
<0.001
Presence of hyperuricemia at incidence/index, (%)
62/616 (10%)
63/510 (12%)
0.22
Use of urate lowering therapy at incidence/index date
7 (1%)
8 (1%)
0.80
Use of urate lowering therapy, ever
28 (3%)
28 (3%)
1.0
Closest to incidence/index date within ±90 days.
**From incidence/index date to last follow-up. IQR: interquartile range; : number; SD: standard deviation; py: person-year; eGFR: estimated glomerular filtration rate.
