Hyperuricemia and Incident Cardiovascular Disease and Noncardiac Vascular Events in Patients with Rheumatoid Arthritis

Table 4

Associations between hyperuricemia and noncardiac vascular disease in patients with rheumatoid arthritis (RA). Data on subjects without RA were omitted as they were only available for part of the study period (1995–2007).

	events in RA	Cerebrovascular events; HR (95% CI)	Peripheral arterial events; HR (95% CI)	Venous thromboembolic events; HR (95% CI)
		49	36	48
Model 1	RA	1.74; (0.93, 3.23)	2.62; (1.27, 5.41)	1.56; (0.83, 2.95)
Model 2	RA	1.39; (0.72, 2.67)	2.52; (1.17, 5.42)	1.27; (0.66, 2.45)
Model 3	RA	1.23; (0.61, 2.46)	2.54; (1.13, 5.70)	1.44; (0.74, 2.81)

Model 1: age, sex, and calendar year adjusted.
Model 2: Model 1, plus being adjusted for smoking, hypertension, obesity (BMI ≥ 30 kg/m²), diabetes mellitus, and dyslipidemia.
Model 3: Model 2, plus being adjusted for eGFR < 60, urate lowering therapy, alcoholism, and low-dose aspirin use.
HR: hazard ratio; CI: confidence interval.