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International Journal of Rheumatology
Volume 2015, Article ID 380354, 5 pages
http://dx.doi.org/10.1155/2015/380354
Research Article

Evaluation of Ovarian Reserve with Anti-Müllerian Hormone in Familial Mediterranean Fever

1Department of Internal Medicine, Rheumatology, Cumhuriyet University Faculty of Medicine, 58140 Sivas, Turkey
2Department of Obstetrics and Gynecology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey
3Department of Physical Medicine and Rehabilitation, Rheumatology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey
4Department of Biochemistry, Cumhuriyet University Faculty of Medicine, Sivas, Turkey

Received 1 March 2015; Accepted 27 April 2015

Academic Editor: Malcolm Smith

Copyright © 2015 Ali Şahin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To investigate ovarian reserves in attack-free familial Mediterranean fever (AF-FMF) patients at the reproductive age by anti-Müllerian hormone (AMH), antral follicle count (AFC), ovarian volume, and hormonal parameters. Methods. Thirty-three AF-FMF patients aging 18–45 years and 34 healthy women were enrolled and FSH, LH, E2, PRL, and AMH levels were measured in the morning blood samples at 2nd–4th days of menstruation by ELISA. Concomitant pelvic ultrasonography was performed to calculate AFC and ovarian volumes. Results. In FMF patient group, median AMH levels were statistically significantly lower in the M69V mutation positive group than in the negative ones (). There was no statistically significant difference in median AMH levels between E148Q mutation positive patients and the negative ones (). There was also no statistically significant difference in median AMH levels between M680I mutation positive patients and the negative ones (). No statistically significant difference was observed in median AMH levels between patients who had at least one mutation and those with no mutations (). We realized that there was no difference in comparisons between ovarian volumes, number of follicles, and AMH levels ovarian reserves when compared with FMF patients and healthy individuals. Conclusions. Ovarian reserves of FMF pateints were similar to those of healthy subjects according to AMH. However, AMH levels were lower in FMF patients with M694V mutation.