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International Journal of Rheumatology
Volume 2016, Article ID 6402963, 7 pages
Research Article

Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness

1Department of Traumatology and Orthopaedics, University of Tartu, Puusepa Street 8, 51014 Tartu, Estonia
2Endothelial Centre, University of Tartu, Tartu, Estonia
3Department of Surgery, University of Tartu, Tartu, Estonia
4Institute of Biomedicine and Translational Medicine and Department of Biochemistry, Centre of Excellence for Genomics and Translational Medicine, University of Tartu, Ravila Street 19, 50411 Tartu, Estonia
5Traumatology and Orthopaedics Clinic, Tartu University Hospital, Tartu, Estonia

Received 5 March 2016; Accepted 12 June 2016

Academic Editor: Bruce M. Rothschild

Copyright © 2016 Kaspar Tootsi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Osteoarthritis (OA) is associated with increased cardiovascular comorbidity and mortality. Evidence is lacking about whether arterial stiffness is involved in OA. The objective of our study was to find out associations between OA, arterial stiffness, and adipokines. Design. Seventy end-stage knee and hip OA patients (age years) and 70 asymptomatic controls (age years) were investigated using the applanation tonometry to determine their parameters of arterial stiffness. Serum adiponectin, leptin, and matrix metalloproteinase 3 (MMP-3) levels were determined using the ELISA method. Correlation between variables was determined using Spearman’s rho. Multiple regression analysis with a stepwise selection procedure was employed. Results. Radiographic OA grade was positively associated with increased carotid-femoral pulse wave velocity (cf-PWV) (, ). We found that OA grade was also associated with leptin and MMP-3 levels (, and , , resp.). In addition, serum adiponectin level was positively associated with augmentation index and inversely with large artery elasticity index (, and , , resp.). Conclusions. Our results suggest that OA severity is independently associated with increased arterial stiffness and is correlated with expression of adipokines. Thus, increased arterial stiffness and adipokines might play an important role in elevated cardiovascular risk in end-stage OA.