Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage

Figure 2

Deferoxamine (DFO) inhibition of type II collagen cleavage by collagenase in human osteoarthritic (OA) articular explants from patients whose ages and genders are indicated (a–e). The means ± SDs for all five patients are shown in (f) (Wilcoxon matched pairs test). Inhibition of type II collagen cleavage by collagenase in human OA articular explants by 10 μM DFO. Cartilages from an additional 15 OA articular cartilage explants were analyzed after exposure to 10 μM DFO. The means ± SDs are shown in (g) (Mann–Whitney test). Significant differences compared to the control () are indicated by asterisks ().

(a)

(b)

(c)

(d)

(e)

(f)

(g)