Research Article

Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage

Table 1

Summary of gene expression in OA articular cartilage explants.

ā€‰Gene expression response in patients treated with DFO
ā€‰DownregulationUpregulationNo changeNo expression

MMP-17000
MMP-136001
Cathepsin K3031
COL10A17000
IL-17000
TNF7000
Glut 11330
PGK13400
PKM22320
IDH3G1501
SDH0700
OGDH0610
MDH20700
AMPK0610
HIF11600
COL2A11510