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International Journal of Rheumatology
Volume 2016, Article ID 7354018, 6 pages
Clinical Study

Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever

1Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt
2Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt
3Department of Rheumatology, Faculty of Medicine, Cairo University, Cairo, Egypt

Received 2 August 2016; Revised 19 November 2016; Accepted 22 November 2016

Academic Editor: Bruce M. Rothschild

Copyright © 2016 Hala M. Lofty et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Objectives. SAA is an acute-phase reactant detected during an FMF attack or other inflammatory conditions. High SAA levels may increase the risk of amyloidosis. The aim of the study is to measure the serum amyloid A (SAA) level in a group of Egyptian children with familial Mediterranean fever (FMF) and study its various correlates, if any. Methods. The study enrolled seventy-one children with FMF. Results. SAA level was high in 78.9% of the studied patients with a mean of  mg/L, and CRP was positive in 31% of patients. There was no significant releation between SAA level and any demographic or clinical manifestation. High SAA was more frequent in V726A allele (16.9%) followed by M694V allele (12.3%). Elevated SAA levels were more frequent in patients on low colchicine doses. Forty-five percent (45%) of patients have low adherence to colchicine therapy. Interpretation and Conclusion. High SAA levels were detected two weeks after last FMF attack in a large percentage of Egyptian FMF children. This indicates that subclinical inflammation continues during attack-free periods, and SAA could be used as a marker of it.