Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation

Table 1

Correlations between area under the concentration/score curve of changes in cartilage marker, bone turnover markers, and joint swelling score.

	Spearman
AUC of markers	CTX-I/Cr (AUC)	CTX-II/Cr (AUC)	DPD/Cr (AUC)	NTX/Cr
Joint swelling score (AUC)	0.673	0.687	0.823	0.743

Correlation coefficients are shown. (Spearman rank correlation); CTX-I, C-telopeptide fragment of type I collagen; CTX-II, C-telopeptide fragment of type II collagen; DPD, deoxypyridinoline; NTX, N-telopeptide fragment of type I collagen; Cr, creatinine; AUC, area under the concentration/score-versus-time curve.