Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation
Table 2
Background data for joint samples.
Histological classification
Mild/none
Moderate
Severe
Histological findings
No change to nonarthritic joint
Fibrillation of articular cartilage, surrounding soft tissue growth
Destruction of joint, invasion of soft tissue into osseous tissue
Animal number
3
6
8
4
9
5
Maximum joint swelling score, all joints (day)
28 (49)
48 (49)
20 (49)
65 (49)
61 (49)
87 (35)
Joint swelling score of distal interphalangeal (DIP) joint
Day 21
0
0
0
0
0
0
Day 35
0
0
0
1
0
1
Day 49
0
0
0
1
0
2
Day 63
0
0
0
1
0
2
Joint swelling score of adjacent proximal interphalangeal (PIP) joint
Day 21
1
0
0
1
0
3
Day 35
1
0
0
3
2
3
Day 49
2
0
1
3
3
3
Day 63
2
0
1
3
3
3
The 2nd finger of the left hand Rigidity of the joints Joint swelling score: 0, no abnormality; 1, swelling not visible but can be determined by touch; 2, swelling slightly visible and can be confirmed by touch; 3, swelling clearly visible; 4, rigidity of the joints.
