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International Journal of Rheumatology
Volume 2017 (2017), Article ID 2323410, 13 pages
Research Article

The Impact of Different Classification Criteria Sets on the Estimated Prevalence and Associated Risk Factors of Diastolic Dysfunction in Rheumatoid Arthritis

1Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
2Rheumatology Division, Universitair Ziekenhuis Brussel (UZB), Vrije Universiteit Brussel (VUB), Brussels, Belgium

Correspondence should be addressed to Aletta M. E. Millen

Received 18 August 2017; Revised 24 October 2017; Accepted 30 October 2017; Published 4 December 2017

Academic Editor: Bruce M. Rothschild

Copyright © 2017 Lebogang Mokotedi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study compared the estimated prevalence and potential determinants of left ventricular (LV) diastolic dysfunction upon applying different classification criteria in rheumatoid arthritis (RA). LV diastolic function was assessed echocardiographically by pulsed Doppler (), tissue Doppler (, lateral and septal ), and left atrial volume index in 176 RA patients. Relationships of traditional cardiovascular risk factors and RA characteristics with LV diastolic function and dysfunction according to previous and current criteria were determined in multivariate regression models. Waist-hip ratio was associated with (standardised (SE) = , ) and lateral (standardised (SE) = , ); low diastolic blood pressure was related to (standardised (SE) = , ). Diastolic dysfunction prevalence differed upon applying previous (59%) compared to current (22%) criteria (). One SD increase in waist-hip ratio was associated with diastolic dysfunction when applying current criteria (OR = 2.61 (95% CI = 1.51–4.52), ), whereas one SD increase in diastolic blood pressure was inversely related to diastolic dysfunction upon using previous criteria (OR = 0.57 (95% CI = 0.40–0.81), ). In conclusion, application of current and previous diastolic dysfunction criteria markedly alters the prevalence and risk factors associated with diastolic dysfunction in RA.