International Journal of Rheumatology / 2017 / Article / Tab 1

Review Article

Tofacitinib versus Biologic Treatments in Moderate-to-Severe Rheumatoid Arthritis Patients Who Have Had an Inadequate Response to Nonbiologic DMARDs: Systematic Literature Review and Network Meta-Analysis

Table 1

Results for monotherapy as obtained with random-effects network meta-analysis at 24 weeks: TOF 5 mg BID and TOF 10 mg BID versus treatment.

Treatment (monotherapy)ACR20
OR (95% CI)
ACR50
OR (95% CI)
ACR70
OR (95% CI)
Withdrawals due to AEs
OR (95% CI)
ACR20
OR (95% CI)
ACR50
OR (95% CI)
ACR70
OR (95% CI)
Withdrawals due to AEs
OR (95% CI)
TOF 5 mg BID versus other treatments TOF 10 mg BID versus other treatments

TOF 5 mg BIDNANANANA1.75 (0.47, 6.68)1.32 (0.33, 5.43)1.72 (0.33, 10.17)2.42 (0.30, 16.27)
TOF 10 mg BID0.57 (0.15, 2.13)0.76 (0.18, 3.02)0.58 (0.10, 2.99)0.41 (0.06, 3.35)NANANANA
TCZ 8 mg/kg Q4W0.54 (0.03, 10.36)0.69 (0.04, 15.01)0.24 (0.01, 13.81)0.06 (0.00, 1.48)0.95 (0.06, 17.60)0.92 (0.05, 20.57)0.42 (0.01, 24.62)0.15 (0.01, 2.74)
CZP 400 mg Q4W0.43 (0.04, 4.19)0.63 (0.06, 8.63)0.21 (0.00, 8.31)0.13 (0.01, 3.89)0.75 (0.07, 7.53)0.84 (0.08, 11.60)0.38 (0.00, 14.99)0.33 (0.01, 7.29)
ETN 25 mg BIW0.31 (0.03, 3.25)0.38 (0.03, 5.17)0.24 (0.00, 6.32)0.61 (0.02, 20.95)0.55 (0.05, 5.69)0.51 (0.04, 6.69)0.42 (0.01, 11.53)1.47 (0.06, 41.85)
ADA 40 mg QW0.76 (0.08, 7.30)0.83 (0.08, 9.62)0.32 (0.01, 7.84)0.11 (0.01, 1.58)1.34 (0.14, 13.42)1.10 (0.11, 12.91)0.57 (0.02, 14.64)0.26 (0.02, 2.90)
ADA 40 mg Q2W1.03 (0.11, 10.06)1.60 (0.14, 18.27)0.53 (0.02, 13.52)0.05 (0.01, 0.51)1.81 (0.19, 17.41)2.10 (0.21, 23.35)0.92 (0.04, 24.17)0.13 (0.01, 0.93)
PLBO3.70 (0.90, 13.16)5.06 (1.25, 20.37)4.36 (0.70, 24.15)0.38 (0.06, 2.88)6.47 (1.61, 23.13)6.69 (1.73, 27.65)7.60 (1.33, 44.03)0.92 (0.15, 5.27)

Comparable;  more effective.
OR > 1 favors TOF 5 mg;  OR < 1 favors TOF 5 mg;  OR > 1 favors TOF 10 mg;  OR < 1 favors TOF 10 mg.

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