International Journal of Rheumatology / 2017 / Article / Tab 2

Review Article

Tofacitinib versus Biologic Treatments in Moderate-to-Severe Rheumatoid Arthritis Patients Who Have Had an Inadequate Response to Nonbiologic DMARDs: Systematic Literature Review and Network Meta-Analysis

Table 2

Results for combination therapy as obtained with random-effects network meta-analysis at 24 weeks: TOF 5 mg BID + DMARDs and TOF 10 mg BID + DMARDs versus treatment.

Treatment (+ DMARDs)ACR20
OR (95% CI)
ACR50
OR (95% CI)
ACR70
OR (95% CI)
Withdrawals due to AEs
OR (95% CI)
ACR20
OR (95% CI)
ACR50
OR (95% CI)
ACR70
OR (95% CI)
Withdrawals due to AEs
OR (95% CI)

TOF 5 mg BID + DMARDs versus other treatments TOF 10 mg BID + DMARDs versus other treatments

TOF 5 mg BIDNANANANA1.28 (0.71, 2.33)1.25 (0.63, 2.45)1.32 (0.74, 2.21)1.00 (0.63, 1.62)
TOF 10 mg BID0.78 (0.43, 1.41)0.80 (0.41, 1.58)0.76 (0.45, 1.35)1.00 (0.62, 1.59)NANANANA
BAR 4 mg QD0.89 (0.31, 2.51)1.01 (0.33, 2.95)1.14 (0.36, 3.06)NA1.15 (0.40, 3.22)1.26 (0.41, 3.71)1.50 (0.45, 3.92)NA
BAR 2 mg QD1.27 (0.45, 3.62)1.77 (0.58, 5.44)1.53 (0.52, 4.27)NA1.64 (0.58, 4.65)2.21 (0.72, 6.82)2.01 (0.67, 5.48)NA
GLB 50 mg Q4W0.75 (0.19, 2.94)0.98 (0.29, 3.22)1.35 (0.33, 5.13)3.10 (0.79, 13.40)0.96 (0.25, 3.74)1.23 (0.36, 4.04)1.78 (0.42, 6.60)3.11 (0.81, 13.48)
TCZ 162 mg Q4W0.91 (0.23, 3.70)0.95 (0.23, 3.89)0.84 (0.24, 2.59)1.37 (0.54, 3.51)1.17 (0.29, 4.79)1.19 (0.28, 4.89)1.10 (0.31, 3.29)1.38 (0.44, 7.45)
TCZ 8 mg/kg Q4W0.83 (0.37, 1.88)0.90 (0.37, 2.21)0.71 (0.28, 1.61)0.97 (0.48, 2.01)1.06 (0.47, 2.41)1.13 (0.46, 2.76)0.93 (0.37, 2.09)0.97 (0.48, 2.04)
CZP 400 mg Q4W0.99 (0.25, 3.84)1.24 (0.25, 5.84)59.16 (2.70, +infty)1.83 (0.44, 7.34)1.27 (0.33, 4.96)1.56 (0.32, 7.32)77.40 (3.53, +infty)1.83 (0.44, 7.45)

TOF 5 mgTOF 10 mg

IFX 3 mg/kg Q8W1.37 (0.50, 3.77)1.56 (0.44, 5.58)1.48 (0.48, 4.34)1.00 (0.35, 2.82)1.76 (0.64, 4.85)1.96 (0.55, 6.97)1.95 (0.62, 5.57)1.00 (0.35, 2.85)
ABT 125 mg QW1.07 (0.37, 3.03)1.00 (0.33, 2.94)1.42 (0.53, 3.34)2.69 (1.12, 6.85)1.37 (0.47, 3.91)1.25 (0.41, 3.67)1.86 (0.68, 4.28)2.70 (1.13, 6.94)
ABT 10 mg/kg Q4W1.42 (0.61, 3.29)1.16 (0.46, 2.90)1.60 (0.65, 3.57)1.84 (0.89, 3.98)1.82 (0.78, 4.21)1.46 (0.57, 3.65)2.10 (0.83, 4.61)1.84 (0.89, 4.03)
ETN 50 mg QW1.36 (0.49, 3.76)1.52 (0.52, 4.47)1.56 (0.57, 4.06)3.17 (0.63, 15.64)1.74 (0.63, 4.84)1.91 (0.65, 5.62)2.04 (0.73, 5.22)3.18 (0.63, 16.07)
ETN 25 mg BIW0.74 (0.28, 1.90)1.01 (0.33, 2.74)1.40 (0.44, 3.47)2.35 (0.94, 5.50)0.96 (0.36, 2.42)1.26 (0.41, 3.40)1.85 (0.56, 4.52)2.36 (0.95, 5.53)
ADA 40 mg Q2W0.82 (0.39, 1.69)0.94 (0.43, 1.99)1.43 (0.68, 2.74)1.38 (0.72, 2.75)1.06 (0.50, 2.17)1.19 (0.53, 2.48)1.87 (0.87, 3.56)1.38 (0.72, 2.78)
PLBO2.88 (1.61, 5.17)4.43 (2.22, 8.78)6.33 (3.21, 12.14)2.04 (1.18, 3.63)3.70 (2.07, 6.61)5.55 (2.76, 10.97)8.29 (4.13, 15.75)2.06 (1.19, 3.66)

Less effective;  comparable;  more effective.
OR > 1 favors TOF 5 mg;  OR < 1 favors TOF 5 mg;  OR > 1 favors TOF 10 mg;  OR < 1 favors TOF 10 mg.

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