Association of clinical characteristics of SSc and 20 DEGs. (a) Heatmaps of gene expression and (b) DNA methylation show the most significant 20 correlated genes for SSc versus Normal. (c) Support vector machines analysis. The y-axis shows the group proportion inferred by SVM and sample ID is on the x-axis. (d) Array-based DNA methylation and mRNA expression among normal controls, the SSc with ILD, and SSc without ILD group, p-value < 0.05 between SSc with and without ILD groups, are showed.