Integration of Genome-Wide DNA Methylation and Transcription Uncovered Aberrant Methylation-Regulated Genes and Pathways in the Peripheral Blood Mononuclear Cells of Systemic Sclerosis

<div><b>Association of clinical characteristics of SSc and 20 DEGs. </b>(a) Heatmaps of gene expression and (b) DNA methylation show the most significant 20 correlated genes for SSc versus Normal. (c) Support vector machines analysis. The y-axis shows the group proportion inferred by SVM and sample ID is on the x-axis. (d) Array-based DNA methylation and mRNA expression among normal controls, the SSc with ILD, and SSc without ILD group,<i> p</i>-value &lt; 0.05 between SSc with and without ILD groups, are showed.</div>

International Journal of Rheumatology

fig5

Figure 5

Figure 5: Integration of Genome-Wide DNA Methylation and Transcription Uncovered Aberrant Methylation-Regulated Genes and Pathways in the Peripheral Blood Mononuclear Cells of Systemic Sclerosis 

Figure 5 | Integration of Genome-Wide DNA Methylation and Transcription Uncovered Aberrant Methylation-Regulated Genes and Pathways in the Peripheral Blood Mononuclear Cells of Systemic Sclerosis 