Integration of Genome-Wide DNA Methylation and Transcription Uncovered Aberrant Methylation-Regulated Genes and Pathways in the Peripheral Blood Mononuclear Cells of Systemic Sclerosis

Figure 6

The diseases and functions analysis by integrated pathway analysis using 20 MeDEGs. (a) The top interaction networks involved by 15 MeDEGs. (b) Canonical pathway analysis of 20 MeDEGs in PBMC from SSc patients as compared with normal controls. Statistically significant pathways were shown. (c) Most genes (12/20) are involved with cell movements of leukocytes, cell movement of antigen presenting cells, migration of phagocytes, chemotaxis of granulocytes, homing of leukocytes, and chemotaxis of neutrophils. (d) The network from 10 DEGs is involved with adhesion of vascular endothelial cells, immune response of leukocytes, activation of leukocytes, immune response of macrophages, and response of myeloid cells. (e) Most genes (12/20) are involved with proliferation of blood cells, cell proliferation of tumor cell lines, and proliferation of epithelial cells. (f) The network from 8 genes is involved with immune response of cells and inflammatory response.

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