Integration of Genome-Wide DNA Methylation and Transcription Uncovered Aberrant Methylation-Regulated Genes and Pathways in the Peripheral Blood Mononuclear Cells of Systemic Sclerosis

Table 1

Characteristics of clinical subjects and healthy controls.

Clinical characteristics	Controls (n=19)	SSc (n=18)
Age (Mean ± SD)	39.8 ± 6.5	46.2 ± 12.4
Sex (M/F)	5/14	7/11
Disease duration (months)	NA	48.7 ± 37.3
Organ involvement
Interstitial lung disease	NA	10
PAH	NA	1
Raynaud’s phenomena	NA	16
Gastrointestinal involvement	NA	9
Digital ulcer	NA	5
Serological characteristics
Anti-Scl-70	NA	12
Anti-RNP	NA	4
Anti-ANA	NA	16
Anti-dsDNA	NA	0
Anti-Jo-1	NA	0
Anti-Sm	NA	0
Anti-SSa	NA	4
Anti-SSb	NA	0
Anti-ANCA	NA	1
Medications
Prednisone	NA	17
Cyclophosphamide	NA	7