Table 2: Differentially expressed gene family in PBMC of SSc patients.

Gene familyGenes

Down-regulatedNK cell associated gene familyCluster of differentiation (CD)CD2, CD96, CD 160
Killer cell lectin like receptors, pseudogeneKLRB1, KLRC1, KLRC2, KLRC3, KLRD1, KLRF1, KLRG1
Killer cell immunoglobulin like receptorsKIR2DL3, KIR2DL5A, KIR2DS1, KIR2DS3, KIR2DS4, KIR3DL1
Natural cytotoxicity triggering receptor 3NCR3
Natural killer cell triggering receptorNKTR
Perforin 1PRF1

Up-regulatedInterferon-induced genesInterferon, alpha-inducible protein 27IFI27
Interferon, gamma-inducible protein 30IFI30
Interferon induced protein 35IFI35
Interferon induced transmembrane protein 3IFITM3
Janus kinase 1JAK1
Ribonuclease A family memberRNASE I, II, III
S100 calcium binding protein A11S100A11
Signal transducer and activator of transcription 4STAT4
Complement componentComplement componentC1QA, C1QB, C1QC, C2, C3AR1, C5AR1
-defensinDefensin αDEFA1, DEFA1B, DEFA3

These CD molecules are also found in T cells.