Integration of Genome-Wide DNA Methylation and Transcription Uncovered Aberrant Methylation-Regulated Genes and Pathways in the Peripheral Blood Mononuclear Cells of Systemic Sclerosis

Table 4

Molecular interaction networks involved by the 20 MeDEGs.

ID	Molecules in Network	Score	Focus Molecules	Top Diseases and Functions
1	C3AR1, Collagen Alpha1, Collagen(s), Cr3, CTSG, CTSZ, Ecm, ELANE, ERK1/2, F2R, Fcer1, Fibrinogen, FYN, IFN Beta, Ige, IL12 (complex), Immunoglobulin, Integrin, LTBR, Mapk, Nfat (family), P38 MAPK, PAG1, Par, PLAUR, PRF1, PRKCH, Pro-inflammatory Cytokine, Ras, RASSF5, RUNX3, SAMD4A, SPI1, SRC, Vegf	41	15	Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking
2	ADCYAP1R1, ADGRL3, Akt, AZU1, caspase, CCL3L1, CD3, CD226, CSDC2, CXCR6, ERK, F2RL3, Gpcr, GPR45, GPR63, HISTONE, IGK, Il8r, Interferon alpha, Jnk, KDM5D, LIME1, NFE2, NFE2L3, NFkB (complex), P2RY10, PI3K (complex), Pkc(s), PRKCH, RNA polymerase II, SIT1, TCR, tubulin, UQCR11, ZYX	8	4	Cell-To-Cell Signaling and Interaction, Cell-mediated Immune Response, Cellular Development
3	ESR1, ODF3B, PKD1	3	1	Connective Tissue Development and Function, Organ Morphology, Skeletal and Muscular System Development and Function
4	CASP1, CEP57, CNOT7, CSTA, CTSB, CTSH, CTSL, CUL2, CUL4B, DSP, FOXR1, GATA2, GLI2, HERC2, HOXA10, Hsp90, IVL, JUND, KRT1, LOR, MAP2K7, MAP3K1, METTL23, MYOC, PI3, PTN, RAD21, RASSF9, RASSF10, TCF3, TCTN3, UCHL5, USP53, ZDHHC17, ZIC1	2	1	Post-Translational Modification, Dermatological Diseases and Conditions, Hereditary Disorder