Table 4: Molecular interaction networks involved by the 20 MeDEGs.

IDMolecules in NetworkScoreFocus MoleculesTop Diseases and Functions

1C3AR1, Collagen Alpha1, Collagen(s), Cr3, CTSG, CTSZ, Ecm, ELANE, ERK1/2, F2R, Fcer1, Fibrinogen, FYN, IFN Beta, Ige, IL12 (complex), Immunoglobulin, Integrin, LTBR, Mapk, Nfat (family), P38 MAPK, PAG1, Par, PLAUR, PRF1, PRKCH, Pro-inflammatory Cytokine, Ras, RASSF5, RUNX3, SAMD4A, SPI1, SRC, Vegf4115Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking

2ADCYAP1R1, ADGRL3, Akt, AZU1, caspase, CCL3L1, CD3, CD226, CSDC2, CXCR6, ERK, F2RL3, Gpcr, GPR45, GPR63, HISTONE, IGK, Il8r, Interferon alpha, Jnk, KDM5D, LIME1, NFE2, NFE2L3, NFkB (complex), P2RY10, PI3K (complex), Pkc(s), PRKCH, RNA polymerase II, SIT1, TCR, tubulin, UQCR11, ZYX84Cell-To-Cell Signaling and Interaction, Cell-mediated Immune Response, Cellular Development

3ESR1, ODF3B, PKD131Connective Tissue Development and Function, Organ Morphology, Skeletal and Muscular System Development and Function

4CASP1, CEP57, CNOT7, CSTA, CTSB, CTSH, CTSL, CUL2, CUL4B, DSP, FOXR1, GATA2, GLI2, HERC2, HOXA10, Hsp90, IVL, JUND, KRT1, LOR, MAP2K7, MAP3K1, METTL23, MYOC, PI3, PTN, RAD21, RASSF9, RASSF10, TCF3, TCTN3, UCHL5, USP53, ZDHHC17, ZIC121Post-Translational Modification, Dermatological Diseases and Conditions, Hereditary Disorder