Effects of the Cathepsin K Inhibitor ONO-5334 and Concomitant Use of ONO-5334 with Methotrexate on Collagen-Induced Arthritis in Cynomolgus Monkeys

<table class="figure-group"><tr class="fig-image" id="a"><td><object data="https://static.hindawi.com/articles/ijr/volume-2019/5710340/figures/5710340.fig.003a.svgz" name="5710340.fig.003a" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(a) </b>All joints (DIP + PIP + MP joints)</td></tr><tr class="fig-image" id="b"><td><object data="https://static.hindawi.com/articles/ijr/volume-2019/5710340/figures/5710340.fig.003b.svgz" name="5710340.fig.003b" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(b) </b>DIP joint</td></tr><tr class="fig-image" id="c"><td><object data="https://static.hindawi.com/articles/ijr/volume-2019/5710340/figures/5710340.fig.003c.svgz" name="5710340.fig.003c" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(c) </b>PIP joint</td></tr><tr class="fig-image" id="d"><td><object data="https://static.hindawi.com/articles/ijr/volume-2019/5710340/figures/5710340.fig.003d.svgz" name="5710340.fig.003d" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(d) </b>MP joint</td></tr></table>

<div>Severity of joint destruction at (a) all, (b) DIP, (c) PIP, and (d) MP joints in collagen-induced arthritis monkeys. The number of all joints (DIP + PIP + MP) was 384 (48 joints/monkey, n=8) in the control and MTX group and 432 (48 joints/monkey, n=9) in the ONO-5334 and ONO-5334/MTX groups.</div>

International Journal of Rheumatology

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Figure 3

Figure 3: Effects of the Cathepsin K Inhibitor ONO-5334 and Concomitant Use of ONO-5334 with Methotrexate on Collagen-Induced Arthritis in Cynomolgus Monkeys 

Figure 3 | Effects of the Cathepsin K Inhibitor ONO-5334 and Concomitant Use of ONO-5334 with Methotrexate on Collagen-Induced Arthritis in Cynomolgus Monkeys 