The Micro-Immunotherapy Medicine 2LARTH® Reduces Inflammation and Symptoms of Rheumatoid Arthritis In Vivo

Figure 4

Histological examination of joints. (a) Histological score was determined based on arthritis severity observed in the sections of knee joints stained with H&E. (b) Quantification of cartilage area in pixel and representative histologic sections of knee joints of three animals per group stained with Safranin-O. The stained cartilage appeared red in color. Representative histologic sections for CIA + vehicle and CIA + MIM are shown next to each graph. More representative histologic sections are shown in Supplementary Materials, see Figures S1 and S2. C = cartilage layer; JS = joint space; black circles indicate inflammation and synovial hyperplasia (pannus formation). Bars in graphs represent mean ± SEM of 3 mice per group. ^∗, .

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