Serum Peptidomic Profile as a Novel Biomarker for Rheumatoid Arthritis

Table 4

Comparison of training set data with other laboratory markers for diagnosing RA.

	RA serum protein peaks	ACPA	RF
Sensitivity (95% CI)	96.66	83.43	80.9
Specificity (95% CI)	100.0	86.67	46.67
PPV	100.0	86.2	61.3
NPV	96.8	83.9	72.0
	<0.001	<0.001	0.004
AUC (95% CI)	0.988	0.875	0.720

RA: rheumatoid arthritis; RF: rheumatoid factor; ACPA: anti-cyclic citrullinated peptide antibody; CI: confidence intervals; NPV: negative predictive value; PPV: positive predictive value; AUC: area under the curve. : statistically significant at .