Research Article
Clinical Outcomes of Myocarditis after Moderate-Dose Steroid Therapy in Systemic Sclerosis: A Pilot Study
Table 4
Clinical data of patients who died.
| | Variable | Case 1 | Case 2 | Case 3 | Case 4 |
| | Sex | Female | Male | Female | Male | | Age on enrollment (years) | 60.2 | 55.1 | 56.4 | 58 | | BMI (kg/m2) | 17.2 | 18.6 | 19.6 | 19.1 | | Duration of disease (years) | 4.5 | 2.8 | 1.7 | 4 | | SSc subset | dcSSc | dcSSc | dcSSc | dcSSc | | Anti-topoisomerase antibody positive | Positive | Positive | Positive | Positive | | Clinical characteristics on an enrollment | | | | | | Tendon friction rub | Yes | Yes | Yes | Yes | | Modified Rodnan skin score (points) | 17 | 21 | 26 | 33 | | Pulmonary involvement | Yes | Yes | Yes | Yes | | Pulmonary arterial hypertension | No | Yes | No | No | | Laboratory results on enrollment | | | | | | Erythrocyte sedimentation rate (mm/hr) | 61 | 47 | 99 | 65 | | C-reactive protein (mg/dl) | 11.3 | 21.8 | 46.4 | 44.7 | | CK-MB (U/L) | 17 | 27 | 161 | 70 | | hs-cTnT (pg/ml) | 42.1 | 181.4 | 1704 | 403.7 | | NT-proBNP (pg/ml) | 4128 | 3306 | 862 | 2410 | | Estimated GFR (ml/min/1.73m2) ; mean±SD | 95.8 | 98.6 | 125.7 | 94.5 | | Cardiomegaly by chest radiography | Yes | No | No | No | | Ground glass opacification by HRCT chest | Yes (<20%) | Yes (<20%) | No | Yes (<20%) | | Echocardiography results on enrollment | | | | | | LV Ejection fraction (%) | 26.1 | 33.5 | 68.0 | 53.5 | | Tricuspid velocity jet (ms) | 1.83 | 2.5 | 2.1 | 2.3 | | Right ventricular systolic pressure (mmHg) | 23.4 | 35 | 20 | 23.4 | | E’ velocity (cm/sec) | NA | NA | NA | 4.8 | | Pericardial effusion | Trivial | No | No | No | | CMR findings on enrollment | | | | | | LV ejection fraction (%) | 30.3 | 31.8 | 66.3 | 64.9 | | LV stroke volume (ml) | 32.9 | 99.5 | 53.9 | 49.5 | | LV cardiac output (L/min) | 2.3 | 4.6 | 6.4 | 3.5 | | LV mass (g) | 100 | 120.5 | 68.5 | 115.8 | | LV mass index (g/m2) | 81.6 | 74.3 | 49.4 | 78.5 | | RV ejection fraction (%) | 30 | 39.2 | 64.7 | 44.6 | | RV stroke volume (ml) | 56.4 | 99.5 | 57 | 47.1 | | RV cardiac output (L/min) | 3.95 | 6.9 | 6.7 | 3.3 | | Pericardial effusion | Moderate | Minimal | Minimal | Minimal | | Duration of death after enrollment (months) | 3.8 | 1.1 | 2 | 3.7 | | Cause of death | Heart failure | Heart failure | Cardiac arrhythmia (VT) | Renal crisis |
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BMI denotes body mass index, CK-MB; creatine kinase-muscle/brain, CMR; cardiovascular magnetic resonance, dcSSc; diffuse cutaneous systemic sclerosis, GFR; glomerular filtration rate, hs-cTnT; high sensitivity of cardiac Troponin-T, HRCT; high resolution computed tomography, LV; left ventricular, NT-proBNP; NT-prohormone-brain natriuretic peptide, RV; right ventricular, SSc; systemic sclerosis, VT; ventricular tachycardia.
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