International Journal of Rheumatology / 2020 / Article / Tab 2

Research Article

Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria

Table 2

Clinical features of mixed connective tissue disease.

SymptomNumber (%),

Central nervous system20 (18)
 Seizure4 (3.6)
 Headache9 (8.1)
 Neuropathy10 (9)
 Meningitis3 (2.7)
Cardiovascular system13 (11.3)
 Myocarditis2 (1.8)
 Pericardial effusion9 (8.1)
 Cor pulmonale1 (0.9)
 Left ventricular failure1 (0.9)
Respiratory system55 (49.5)
 Pleural effusion7 (6.3)
 Interstitial lung disease43 (38.7)
 Pulmonary arterial hypertension9 (8.1)
Hematological system24 (21.6)
 Autoimmune hemolytic anemia21 (18.9)
 Immune thrombocytopenia5 (4.5)
Gastrointestinal and hepatobiliary system62 (56)
 Hepatitis19 (17.1)
 Autoimmune hepatitis11 (9.9)
 Esophageal dysmotility32 (28.8)
Genitourinary system19 (17.1)
 Glomerulonephritis19 (17.1)
Skin and mucosal system87 (78.4)
 Malar rash27 (24.3)
 Sicca symptoms16 (14.4)
 Mucosal ulcerations34 (30.6)
 Alopecia30 (27)
 Sclerodactyly41 (36.9)
 Raynaud’s phenomenon74 (66.7)
 Digital gangrene5 (4.5)
Musculoskeletal system106 (95.5)
 Arthritis77 (69.4)
 Myositis42 (37.8)
 Swollen fingers22 (19.8)
Miscellaneous
 Fatigue27 (24.3)
 Lymphadenopathy11 (9.9)
 Fever at presentation51 (45.9)

Four patients had trigeminal neuropathy. All patients had predominant lower zone involvement. Seven patients had membranous glomerulonephritis. Six had mesangioproliferative glomerulonephritis, and 2 had focal segmental glomerulonephritis. Six patients had deforming arthritis.

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