Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria
Table 2
Clinical features of mixed connective tissue disease.
Symptom
Number (%),
Central nervous system
20 (18)
Seizure
4 (3.6)
Headache
9 (8.1)
Neuropathy
10 (9)
Meningitis
3 (2.7)
Cardiovascular system
13 (11.3)
Myocarditis
2 (1.8)
Pericardial effusion
9 (8.1)
Cor pulmonale
1 (0.9)
Left ventricular failure
1 (0.9)
Respiratory system
55 (49.5)
Pleural effusion
7 (6.3)
Interstitial lung disease
43 (38.7)◇
Pulmonary arterial hypertension
9 (8.1)
Hematological system
24 (21.6)
Autoimmune hemolytic anemia
21 (18.9)
Immune thrombocytopenia
5 (4.5)
Gastrointestinal and hepatobiliary system
62 (56)
Hepatitis
19 (17.1)
Autoimmune hepatitis
11 (9.9)
Esophageal dysmotility
32 (28.8)
Genitourinary system
19 (17.1)
Glomerulonephritis
19 (17.1)□
Skin and mucosal system
87 (78.4)
Malar rash
27 (24.3)
Sicca symptoms
16 (14.4)
Mucosal ulcerations
34 (30.6)
Alopecia
30 (27)
Sclerodactyly
41 (36.9)
Raynaud’s phenomenon
74 (66.7)
Digital gangrene
5 (4.5)
Musculoskeletal system
106 (95.5)
Arthritis▲
77 (69.4)
Myositis
42 (37.8)
Swollen fingers
22 (19.8)
Miscellaneous
Fatigue
27 (24.3)
Lymphadenopathy
11 (9.9)
Fever at presentation
51 (45.9)
Four patients had trigeminal neuropathy. ◇All patients had predominant lower zone involvement. □Seven patients had membranous glomerulonephritis. Six had mesangioproliferative glomerulonephritis, and 2 had focal segmental glomerulonephritis. ▲Six patients had deforming arthritis.
