Effect of Polymorphisms in the FCN1, FCN2, and FCN3 Genes on the Susceptibility to Develop Rheumatoid Arthritis: A Systematic Review

Table 3

Allelic and genotypic frequencies of cases and controls.

Study data						Cases							Controls
Author	Year	Gene	RS	Alleles	Risk allele	Cases	Total alleles	Allele ref	Risk allele	WT	HT	HH	Control	Total alleles	Allele ref	Risk allele	WT	HT	HH
Addobbati C	2015	FCN1	rs2989727	C/T	T	137	274	124	150	27	70	40	264	528	206	322	40	126	98
			rs1071583	C/T	T	137	274	165	109	50	65	22	264	528	341	187	109	123	132
		FCN2	rs17514136	A/G	G	184	368	286	82	108	70	6	264	528	401	127	156	89	19
			rs3124954	C/T	T	184	368	241	127	84	73	27	264	528	345	183	116	113	35
			rs7851696	G/T	T	184	368	318	50	136	46	2	264	528	458	70	197	64	3
Pieczarka C	2020	FCN1	rs2989727	G/A	A	148	296	152	144	35	82	31	159	318	147	171	38	71	50
			rs10120023	G/A	A	148	296	230	66	89	52	7	159	318	224	94	74	76	9
			rs17039495	G/A	A	148	296	288	8	140	8	0	159	318	316	2	157	2	0
			rs10117466	C/A	A	148	296	234	62	93	48	7	159	318	232	86	81	70	8
			rs10858293	G/T	T	148	296	226	70	83	60	5	159	318	226	92	78	70	11
		FCN3	rs532781899	g.1637C/g.1637del	g.1637del	148	296	290	6	142	6	—	160	320	312	8	153	7	—
			rs28362807	g.3524_3532ins	g.3524_3532ins	148	296	210	86	75	60	13	160	320	244	76	96	52	12
			rs4494157	g.4473C/g.4473A	g.4473A	148	296	215	81	79	57	12	160	320	250	70	102	46	12
Vander Cruyssen B	2007	FCN1	rs2989727	G/A	A	338	676	226	450	145	162	31	595	1190	476	714	220	268	107
			rs1071583	A/G	G	338	676	216	460	152	156	30	595	1190	464	726	226	274	95
		FCN2	rs7865453	A/C	C	338	676	616	60	—	—	—	595	1190	1048	142	—	—	—
			rs32469537	A/G	G	338	676	480	196	—	—	—	595	1190	880	310	—	—	—
			rs17549193	C/T	T	338	676	466	210	—	—	—	595	1190	880	310	—	—	—
			rs7851696	G/T	T	338	676	608	68	—	—	—	595	1190	1036	154	—	—	—
		FCN3	rs3813800	C/G	G	338	676	676	0	—	—	—	595	1190	1178	12	—	—	—

WT: wild-type genotype or homozygous for the major allele; HT: heterozygous genotype; HH: genotype homozygous for the risk allele.