Effect of Polymorphisms in the FCN1, FCN2, and FCN3 Genes on the Susceptibility to Develop Rheumatoid Arthritis: A Systematic Review

Table 4

Genotype and allele distributions of variants FCN1 gene in cases and control groups.

FCN1 (rs2989727)
Model	Genotype allele	Cases	Control	OR	95% CI	value	Chi^2
Codominant	C/C	207	298	1	Reference
	C/T	314	465	0.965	0.768-1.213	0.765	0.088
	T/T	102	255	0.577	0.430-0.769	0.0002	14.025
Dominant	C/C	207	298	0.831	0.671-1.030	0.0922	2.835
	C/T+T/T	416	720
Recessive	C/C+C/T	521	763	0.585	0.452-0.756	0.00005	17.093
	T/T	102	255
Overdominant	C/C+T/T	309	553	1.208	0.989-1.475	0.0629	3.457
	C/T	314	465
Allele	T	518	975	0.774	0.671-0.892	0.0004	12.431
FCN1 (rs1071583)
Model	Genotype allele	Cases	Control	OR	95% CI	value	Chi^2
Codominant	T/T	80	204	1	Reference
	T/C	221	397	1.419	1.044-1.928	0.024	5.043
	C/C	174	258	1.719	1.246-2.372	0.0009	10.975
Dominant	T/T	80	204	1.537	1.153-2.049	0.0032	8.706
	T/C+C/C	395	655
Recessive	T/T+T/C	301	601	1.346	1.062-1.706	0.013	6.078
	C/C	174	258
Overdominant	T/T+C/C	254	462	1.012	0.808-1.267	0.913	0.011
	T/C	221	397
Allele	C	569	913	1.316	1.123-1.546	0.0008	11.292