The Need for Laparoscopic Ovarian Transposition in Young Patients with Cervical Cancer Undergoing Radiotherapy

Table 1

Studies reporting the outcome of lateral ovarian transposition in patients with cervical cancer.

Author	Procedure	Number of subjects	Position of transposed ovary/ovaries	Therapy	Outcome
Feeney et al. [29]	Lateral ovarian transposition following hysterectomy	28	To the paracolic gutter	RT/RH + RT	Ovarian preservation was achieved in 14/28 (50%) patients
Fujiwara et al. [28]	Subcutaneous ovarian transposition following hysterectomy	27	To the fascia of the abdominal tissue	RT + RH	Only 12 patients (44%) had normal ovarian function
Anderson et al. [23]	Ovarian transposition	82	Sutured to the posterior peritoneum, above the pelvic brim at the level of the lower pole of the kidney	RT	Ovarian preservation was achieved in 53% of subjects. Painful ovarian cyst occurred in 20% of cases. There was one case of ovarian metastasis (1.2%)
Huang et al. [24]	Laparoscopic bilateral ovarian transposition	14 (<45 years old)	To a high anterolateral position, 3-4 cm above the umbilical line	CCRT/RT/RH + RT/NCT + RH + RT	No intraoperative or postoperative complications occurred. No metastasis was observed. All patients tolerated the procedure. Seven of the 14 patients (50%) developed ovarian failure, shown by the elevation of FSH level
Morice et al. [31]	Bilateral ovarian transposition	107 (21–42 years old)	To the paracolic gutter (laparotomy, 102 cases; laparoscopy, 5 cases)	RT/RH + RT	One case (1%) with ovarian metastasis. No other postoperative complications occurred. Ovarian function preservation was achieved in 83% of patients
Morice et al. [33]	Bilateral ovarian transposition	24	To the paracolic gutter (laparoscopy)	RT/RH + RT/NCT + RT + RH	Ovarian preservation was achieved in 79% patients; three pregnancies were obtained
Chambers et al. [25]	Lateral ovarian transposition (by laparotomy)	34	Below and above the iliac crest	RT/RH + RT/CCRT	Ovarian preservation was achieved in 71%. Symptomatic ovarian cyst occurred in 18% of cases
Clough et al. [30]	Laparoscopic unilateral (right) ovarian transposition	20	To the paracolic gutter	RT	There were (18/20; 85.3%) cases with normal ovarian function. No postoperative complication was observed
van Eijkeren et al. [34]	Lateral ovarian transposition following hysterectomy	18	To the abdominal sidewall at the level of the lowest rib	RT	Ovarian preservation was achieved in 13/18 (72%) patients

CCRT: concurrent chemotherapy radiotherapy (adding cisplatin as radio sensitizer with a dose of 50 mg/m² weekly for 6 courses); RT: radiotherapy; RH: radical hysterectomy; NCT: neoadjuvant chemotherapy (combined cisplatin 50 mg/m², vincristine 1 mg/m², and bleomycin 25 mg/m² in an interval of 10 days, 3 courses in total).