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International Journal of Reproductive Medicine
Volume 2014, Article ID 367474, 7 pages
Clinical Study

Comparison of Results of Cycles Treated with Modified Mild Protocol and Short Protocol for Ovarian Stimulation

1Centro de Infertilidade e Medicina Fetal do Norte Fluminense, Hospital Escola Álvaro Alvim, Rua Barão da Lagoa Dourada, 409-2 ° pavimento, Centro, 28035-210 Campos dos Goytacazes, RJ, Brazil
2Centro Colombiano de Fertilidad y Esterilidad (CECOLFES) S.A.S., Calle 102 No. 14A-15, 56769 Bogota, Colombia

Received 21 January 2014; Revised 7 July 2014; Accepted 12 July 2014; Published 6 August 2014

Academic Editor: Dimitris Loutradis

Copyright © 2014 F. Coelho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The ovarian stimulation has been applied in order to increase the number of oocytes to compensate for the poor results of in vitro fertilization, allowing the selection of one or more embryos to be transferred. Our aim is to compare the results obtained in IVF/ICSI cycles using the short protocol for controlled ovarian stimulation to the results from the modified mild protocol used in our department. A total of 240 cycles were conducted from January 2010 to December 2011. When comparing both protocols, it could be observed that there was a significant difference in the quantity of gonadotropins doses in the mild protocol and in the short protocol. No significant difference was observed regarding pregnancy rates per cycle, 22% and 26.2%, in short and mild protocols, respectively. The protocols of controlled ovarian stimulation are often associated with high risk of complications such as ovarian hyperstimulation syndrome, excessive emotional stress, high rates of treatment dropouts, and abdominal discomfort. With the data obtained in this study, one can conclude that there are less risks and complications for the patient when using the mild stimulation protocol. It was also observed that in this group there was a slightly higher rate.