Combined Intranasal Insulin/Saxagliptin/Metformin Therapies Ameliorate the Effect of Combined Oral Contraceptive- (COC-) Induced Metabolic Syndrome (MetS) with a Major Target on Glucose Metabolism in Adult Female Wistar Rats

Figure 8

(a) COC caused a significant decrease in glucokinase level when compared with control (); this decrease was not reversed by any of the treatment group () when compared with the COC group. (b) COC increased the G6P level (); this effect was reversed significantly by the INI+SAX group (^##). (c) COC increased the GLUT4 levels significantly (); this effect was reversed in INI+MET () and INI+SAX (^##) (, ).

(a)

(b)

(c)