Hereditary Pancreatic and Hepatobiliary Cancers

Table 1

Epidemiological studies of HPC.

Study, year [ref]	Type	Location	No. of patients	Findings
Falk, 1988 [9]	Case control	Louisiana, USA	363	OR 5.25 if FH
Lynch, 1990 [10]	Descriptive	Nebraska, USA	47	10-fold increased occurrence of PC if FH of PC (7.8% versus 0.6%)
Ghadirian, 1991 [11]	Case control	Montréal, Canada	179	13-fold increased occurrence of PC if FH of PC (6.7% versus 0.7%)
Fernandez, 1994 [12]	Case control	Italy	362	4-fold increased occurrence of PC if FH of PC (3.9% versus 1.1%); RR 3 if FH
Dergham, 1997 [13]	Case series	Detroit, USA	81	9% occurrence of PC if FH of PC.
Coughlin, 2000 [14]	Cohort	USA	3751	RR 1.5 (men)–1.7 (women) if FH
Hemminki, 2003 [15]	Cohort	Sweden	21,000	SIR 2.4 if FH (parent)
Klein, 2004 [16]	Registry	Baltimore, USA	5179	SIR 32 if 3 FDR with PCSIR 6.4 if 2 FDR with PCSIR 4.5 if 1 FDR with PC
Permuth-Wey, 2008 [17]	Meta-analysis	USA, Italy, Canada, Japan	6568	RR 3.4 if FH of PC

OR: odds ratio; RR: relative risk; SIR: standardized incidence ratio; FH: family history; FDR: first-degree relative.