Review Article
Molecular Markers in Cutaneous Squamous Cell Carcinoma
Table 1
High risk factors for NMSC tumor characteristics*.
| Histologic differentiation | | Poor differentiation | | Spindle cell characteristics | | Necrosis | | High mitotic activity | | Deep invasion | | Depth of invasion | | >2 mm | | Clark level 3IV | | Perineural invasion | | High risk anatomic sites | | Nonglabrous Lip | | Ear | | Advanced T stage (T3 and T4) | | Bony extension or involvement | | Maxilla, mandible, orbit, temporal bone | | Perineural invasion | | Invasion of skull base | | Invasion of axial or appendicular skeleton | |
|
|
*7th Edition of American Joint Commission on Cancer Staging Manual [18].
|