International Journal of Surgical Oncology / 2011 / Article / Tab 1

Review Article

Molecular Markers in Cutaneous Squamous Cell Carcinoma

Table 1

High risk factors for NMSC tumor characteristics*.

Histologic differentiation
 Poor differentiation
 Spindle cell characteristics
 Necrosis
 High mitotic activity
 Deep invasion
Depth of invasion
 >2 mm
 Clark level 3IV
Perineural invasion
High risk anatomic sites
 Nonglabrous Lip
 Ear
Advanced T stage (T3 and T4)
 Bony extension or involvement
 Maxilla, mandible, orbit, temporal bone
 Perineural invasion
 Invasion of skull base
 Invasion of axial or appendicular skeleton

*7th Edition of American Joint Commission on Cancer Staging Manual [18].

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