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International Journal of Surgical Oncology
Volume 2011, Article ID 285840, 12 pages
Review Article

Colorectal Liver Metastases

1Department of Surgery, Saint Agnes Hospital, Baltimore, MD 21229, USA
2Department of Surgery, Johns Hopkins University, Baltimore, MD 21231, USA
3Pancreatic and Hepatobiliary Surgery, Saint Agnes Hospital, 900 Caton Avenue, Mailbox no. 207, Baltimore, MD, 21229, USA

Received 6 December 2010; Accepted 22 March 2011

Academic Editor: S. Curley

Copyright © 2011 Ashraf J. Haddad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The diagnosis and management of CRLM is complex and requires a multidisciplinary team approach for optimal outcomes. Over the past several decades, the 5-year survival following resection of CRLM has increased and the criteria for resection have broadened substantially. Even patients with multiple, bilateral CRLM, previously thought unresectable, may now be candidates for resection. Two-stage hepatectomy, repeat curative-intent hepatectomy, and even selected resection of extrahepatic metastases have further increased the number of patients who may be treated with curative intent. Multiple liver-directed therapies exist to treat unresectable, incurable patients with adequate survival benefit and morbidity rates.