International Journal of Surgical Oncology / 2011 / Article / Tab 1

Review Article

Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review

Table 1

Clinicopathologic characteristics of hereditary versus sporadic breast and ovarian cancer.

Breast cancerOvarian cancer

Average age of diagnosisBRCA1 BRCA1
BRCA2 BRCA2

Pathological features differentiation grade, stage
↑ bilateral tumours? ↑ papillary serous serology
↑ # lymph nodes

Receptor statusBRCA1: ↑ ER−/PR−/HER2−
BRCA2: similar to sporadic tumours

Survival progression free-survival↑ progression-free survival
overall survival↑ overall survival

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