Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review

Table 2

Clinical features that warrant referral for genetic testing for BRCA1/2 mutations.

(i) Early-onset breast cancer, usually defined as before age 50 or 45
(ii) Ovarian, fallopian tube or primary peritoneal cancer
(iii) Individuals with two or more primary breast cancers, or breast and ovarian cancer in the same individual
(iv) Male breast cancer
(v) Two or more individuals in the family with breast and/or ovarian cancer
(vi) Ashkenazi Jewish ancestry