Gastrointestinal Complications in 147 Consecutive Patients with Peritoneal Surface Malignancy Treated by Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy

Table 4

Comparison with other series with more than 100 patients.

Author	Institution	Year	Patient revised	Histology	GI Events Revised	GI Morbidity Grades III-IV	Risk Factor for GI Events	Statistical Analysis
Glehen et al. [23]	Lyon	2003	207	Colon, PMP, ovarian	Digestive fistula (14); Prolonged ileus (11); Intraperitoneal abscess (5)	*15%; 30 events	Carcinomatosis stage; Duration of surgery; Number of anastomosis	Univariate
Kusamura et al. [24]	Milan	2006	205	PM, PMP, ovarian	Anastomotic leak (17); Digestive perforations (6); Biliary fistula (1); pancreatic fistula (2); Ileus/gastric stasis (4)	*15%; 30 events	Extent of cytoreduction; CDDP IPHP dose	Multivariate
Hansson et al. [25]	Uppsala	2009	123	Colorectal, PMP, PM, ovarian	Anastomotic leak (7); Digestive perforation (11); Pancreatitis (1); Bile leak (1); Ileus (3)	*19%; 23 events	Stoma formation; Duration of surgery; Perioperative blood loss; PCI	Multivariate
Youssef et al. [26]	Basingstoke	NP	456 Just 441 had resections	PMP (appendix)	Anastomotic leak (7); Pancreatic complicate (5); Intestinal fistula (8)	4.5%; 20 events	NA
Present series	Washington	2011	147	Colon, PMP (appendix)	Anastomotic failure (2); Fistula (4); Pancreatic fistula (1); Pancreatitis (1); Bile leak (1); Chyle leak (0); Prolonged ileus (0); Small bowel obst (1); Vomiting (5); Diarrhea (0); Ascites (0)	8%; 15 events	Grade; PCI; Small bowel resection; Colorectal anastomoses; Number of anastomosis per patient	Multivariate

* Percentage calculated from total number of events/total number of patients.
NP: Not published. NA: Not available. CDDP: cisplatin, IPHP: intraperitoneal hyperthermic perfusion. PM: peritoneal mesothelioma. PMP: pseudomyxoma peritonei