Review Article

Selection Criteria for the Radical Treatment of Locally Advanced Rectal Cancer

Table 2

Outcomes in pelvic exenteration surgery.

Study Tumour typeProcedure typeMorbidityMortality5-year survivalLR rateAdverse prognostic features

Austin and Solomon [31]36All pelvicAll70%0%69%28%n/a
Bakx et al. [43]40Rec. rectalAll83%6%28%n/aPositive CRM, symptomatic recurrence at surgery, peripheral recurrence
Bannura et al. [44]301° rectalPPE50%0%48%30%n/a
Derici et al. [40]571° rectalAll32%3.5%49%18%Positive CRM, node positive
Eckhauser et al. [45]121° rectalPPE, TPE75%8%50%36%n/a
Ferenschild et al. [46]69All pelvicTPE67%0%38%30%Positive CRM
Ferenschild et al. [47]251° and rec. rectalAll and sacrectomy68%0%30%66%Node positive, positive CRM
Gannon et al. [7]451° and rec. rectalPPE, TPE47%0%52%22%n/a
Harris et al. [12]421° rectalPPE, TPE49%0%48%7%Metastases, node positive, EMVI
Ike et al. [48]711° rectalTPE66%4%54%28%Age, tumour stage, node positive,
Ishiguro et al. [49]911° rectalPPE,TPE41%2%52%54%Lateral pelvic LN positivity, raised CEA, EMVI
Larsen et al. [41]1241° rectalPPE, TPE41%2.5%52%15%Age, annular tumour, poor differentiation, pelvis side wall resection, transfusion
Law et al. [50]241° and rec. rectalAll54%0%44%n/an/a
Maetani et al. [51]61Rec. rectalAlln/a3%28%41%n/a
Melton et al. [52]29Rec. rectalTPE and sacrectomy59%3.5%20%85%Transfusion, positive CRM, bone invasion, anterior organ invasion
Moriya et al. [53]1281° rectalAll27%1%57%34%BMI, node positive, inflammatory reaction
Nguyen et al. [11]76All pelvicAll28%0%53%n/an/a
Roos et al. [54]351° and rec. rectalAll69%3%52%12%Positive CRM, preoperative pain
Verschueren et al. [55]111° rectalPPE, TPE27%9%68%9%n/a
Wiig et al. [56]61° rectalLAR/APR and prostatectomy66%0%83%n/an/a
Påhlman et al. [33]28All pelvicAll54%7%n/an/an/a
Yamada et al. [5]641° and rec. rectalTPE, PPE, and sacrectomy56%2%39%n/an/a

APE: anterior pelvic exenteration, PPE: posterior pelvic exenteration, TPE: total pelvic exenteration, All: APE, PPE, TPE, LAR: low anterior resection, APR: abdominoperineal.