Surgical Management of Appendicular Skeletal Metastases in Thyroid Carcinoma

Table 4

Univariate Cox model.

Prognostic factors	Overall survival			Time to bone; metastasis			Survival after bone; metastasis surgery			Recurrence free survival
	Hazard; ratio	95% CI	𝑃 value	Hazard; ratio	95% CI	𝑃 value	Hazard; ratio	95% CI	𝑃 value	Hazard; ratio	95% CI	𝑃 value
Age	1.06	1.02–1.09	0.001	1.06	1.005–1.116	0.032	1.002	0.975–1.03	0.864	1.012	0.98–1.04	0.41
Gender; F v M	1.19	0.55–2.38	0.66	0.63	0.21–1.83	0.39	1.63	0.76–3.50	0.21	1.795	0.87–3.7	0.113
Follicular subtype	1.1	0.51–2.37	0.81	1.26	0.43–3.71	0.68	0.83	0.40–1.73	0.63	1.33	0.63–2.81	0.45
Radioactive iodine Y v N	0.18	0.05–0.61	0.006	0.07	0.005–1.186	0.066	0.54	0.18–1.62	0.27	0.504	0.16–1.53	0.23
Other treatment Y v N	1.51	0.63–3.62	0.36	1.721	0.55–5.34	0.35	0.95	0.40–2.25	0.91	0.72	0.29–1.78	0.48
Skeletal presentation; Multiple bone v single							2.44	0.93–6.44	0.07	3.03	1.03–8.92	0.044
Preoperative radiation to bone Y v N							1.985	0.73–5.38	0.18	1.74	0.65–4.68	0.27
Tumor excised from bone; Y v N							0.21	0.075–0.58	0.003	0.28	0.11–0.75	0.012