Intraductal Proliferative Lesions of the Breast—Terminology and Biology Matter: Premalignant Lesions or Preinvasive Cancer?

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">DIN system</td><td align="center">Traditional terminology</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">Usual ductal hyperplasia (UDH)</td><td align="center">Epitheliosis<br/>Infiltrating epitheliosis<br/>Papillomatosis<br/>Sclerosing adenosis with pseudoinfiltration<br/>Sclerosing papillary proliferation</td></tr><tr><td align="center" colspan="2"><hr/></td></tr><tr><td align="left">DIN1a</td><td align="center">Clinging carcinoma monomorphus or type 2<br/>Flat epithelial atypia<br/>Atypical cystic lobules<br/>Atypical lobules type A<br/>Atypical columnar change</td></tr><tr><td align="center" colspan="2"><hr/></td></tr><tr><td align="left">DIN1b</td><td align="center">Atypical ductal hyperplasia (ADH) </td></tr><tr><td align="center" colspan="2"><hr/></td></tr><tr><td align="left">DIN1c</td><td align="center">Low-grade ductal carcinoma in situ (LG-DCIS) <br/>DCIS grade 1</td></tr><tr><td align="center" colspan="2"><hr/></td></tr><tr><td align="left">DIN2</td><td align="center">Intermediate-grade ductal carcinoma in situ (IG-DCIS) <br/>DCIS grade 2</td></tr><tr><td align="center" colspan="2"><hr/></td></tr><tr><td align="left">DIN3</td><td align="center">High-grade ductal carcinoma in situ (HG-DCIS) <br/>DCIS grade 3</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

International Journal of Surgical Oncology

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Table 1: Intraductal Proliferative Lesions of the Breast—Terminology and Biology Matter: Premalignant Lesions or Preinvasive Cancer? 