Investigational Paradigms in Downscoring and Upscoring DCIS: Surgical Management Review

Table 2

Author and reference	Parameter	Results
Ottesen et al. [15]	Size	10-year LR rates of DCIS treated by BCS alone (𝑛=275)
	<10 mm	LR 11%
	>10 mm	LR 48%
Cutuli et al. [29]	Size	5-year LR rates of BCS versus BCS + RT groups (𝑛=1,289)
	<10 mm	LR 30%		LR 11%
	>10 mm	LR 31%		LR 13%
Dunne et al. [18]	Margin	Optimum margin threshold for DCIS resection (𝑛=2,514)
Number of patients	Negative Margin Width	Percentage of patients with IBTR (5-year follow-up)
914	No cells on ink	9.4
1,239	1 mm margin	10.4
207	2 mm margin	5.8
154	≥5 mm margin	3.9
Kerlikowske et al. [57]	Nuclear Grade	Invasive LR rates of DCIS treated by BCS alone (𝑁=1491)
MacDonald et al. [43]
	Low-grade lesions	6%
	High-grade lesions	31.5%
Silverstein et al. [1]	VNPI Score	LR rates and DFS in three groups of DCIS patients (𝑁=238)
(1) Non-high-grade DCIS without comedo-type necrosis				3.8%	93%
(2) Non-high-grade DCIS with comedo-type necrosis				11.1%	84%
(3) High-grade DCIS with or without comedo-type necrosis				26.5%	61%