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International Journal of Surgical Oncology
Volume 2012, Article ID 748196, 5 pages
http://dx.doi.org/10.1155/2012/748196
Review Article

Role of the Radiotherapy Boost on Local Control in Ductal Carcinoma In Situ

1Département d’Oncologie Radiothérapie, CRLC Val d’Aurelle-Paul Lamarque, 34298 Montpellier, France
2Département de Recherche Clinique, CRLC Val d’Aurelle-Paul Lamarque, 34298 Montpellier, France

Received 2 December 2011; Accepted 23 January 2012

Academic Editor: Bruno Cutuli

Copyright © 2012 Olivier Riou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ductal carcinoma in situ of the breast is associated with low mortality rates, but local relapse is a matter of concern in this disease. Risk factors for local relapse include young age, close or positive margins, and tumor necrosis. Whole breast irradiation following breast-conserving surgery for ductal carcinoma in situ significantly reduces the risk of local relapse as compared to breast-conserving surgery alone. Studies point to similar outcomes between breast-conserving surgery plus radiotherapy and mastectomy, in the absence of extensive disease. A complementary boost to the surgical bed improves outcomes for patients with invasive breast cancer. However, the effect of this strategy has never been prospectively reported for ductal carcinoma in situ. Two randomized controlled trials assessing this issue are ongoing. This paper represents an update on available literature about radiotherapy for DCIS with a special focus on the role of a radiotherapy boost to the tumor bed.