Resection of Nonalcoholic Steatohepatitis-Associated Hepatocellular Carcinoma: A Western Experience

Table 4

Pathological data and longterm outcomes.

Patient	1	2	3	4	5	6	7	8	9
Tumor size (cm)	5.1	1.8	6.2	6.0	4.5	6.3	19.0	6.0	8.4
Number of nodules	1	1	1	1	2	1	1	1	1
Vascular invasion	None	None	Micro	None	Gross	Micro	Gross	Micro	Micro
Satellites	Yes	No	Yes	No	No	No	Yes	No	No
Tumor cell differentiation^a	Well	Well	Well	Mod	Mod	Mod	Poor	Mod	Mod
Steatotic tumor cells	No	Yes	Yes	No	No	No	No	Yes	Yes
Parenchymal fibrosis^b	F4	F4	F4	F1	F3	F3	F1	F1	F1
Margin (mm)	3	5	0	20	10	10	10	2	2
Regional lymph nodes (+)	No	No	No	No	No	No	No	No	No
Metastases	No	No	No	No	No	No	Yes	No	No
Recurrence gg	Yes	Yes	Yes	No	Yes	Yes	No	Yes	Yes
Time to recurrence (months)	19.4	6.4	8.3	—	6.2	37.9	—	6.2	16.8
Distribution of 1st recurrence	IH	IH	IH	—	IH	IH	—	IH/EH	IH
Treatment of 1st recurrence	TACE	OLT	TACE	—	RR	RFA	—	RR	RFA
Survival (months)	105.2	32.3	27.8	84.0	62.1	68.0	1.1	34.7	38.3

Micro: microscopic, Mod: moderate, IH: intrahepatic, EH: extrahepatic, TACE: transarterial chemoembolization, OLT: orthotopic liver transplant, RR: repeat resection, RFA: radiofrequency ablation.
^aBased on Edmonson grading system, ^bbased on Brunt criteria.