The Role of Surgery, Radiosurgery and Whole Brain Radiation Therapy in the Management of Patients with Metastatic Brain Tumors

Table 1

Randomized Trials for Treatment of Brain Metastases.

Author	Treatment	Local Control (1 yr)	Distant Brain Failure (1 yr)	Overall Survival
Patchell [19]	WBRT	48%	13%	9% (1 yr)
	Surgery plus WBRT	80%	20%	45%
Vecht [22]	WBRT	NA	NA	23% (1 yr)
	Surgery plus WBRT	NA	NA	50%
Mintz [17]	WBRT	NA	NA	17% (1 yr)
	Surgery plus WBRT	NA	NA	30%
Patchell et al. [18]	Surgery	54%	37%	43 wks
	Surgery plus WBRT	90%	14%	48 wks (median)
Andrews et al. [30]	WBRT	71%	33%	23% (1 yr)
	WBRT plus SRS	82%	27%	29%
Kocher et al. [35]	SRS	70%	44%	47% (1 yr)
	SRS plus WBRT	87%	28%	46%
Chang et al. [36]	SRS	67%	55%	60% (1 yr)
	SRS plus WBRT	100%	27%	21%
Aoyama et al. [34]	SRS	76%	63%	28% (1 yr)
	SRS plus WBRT	90%	42%	39%