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International Journal of Surgical Oncology
Volume 2014 (2014), Article ID 545372, 6 pages
http://dx.doi.org/10.1155/2014/545372
Clinical Study

Close Margins in Oral Cancers: Implication of Close Margin Status in Recurrence and Survival of pT1N0 and pT2N0 Oral Cancers

1Basavatarakam Indo American Cancer Hospital and Research Centre, Hyderabad, Andhra Pradesh 500034, India
2Seven Hills Hospital, Andheri West, Mumbai, India

Received 12 July 2014; Revised 17 October 2014; Accepted 20 October 2014; Published 11 November 2014

Academic Editor: Steven Heys

Copyright © 2014 Sandhya Gokavarapu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, “Global cancer statistics,” CA: Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Farlay, F. Bray, P. Pisani et al., GLOBOCAN 2002: Cancer Incidence, Mortality and Prevalence Worldwide, Version 1.0, IARC Cancer Base no. 5, IARC Press, Lyon, France, 2004.
  3. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 89, World Health Organization, 2007.
  4. J. Watkinson and R. Gilbert, “Stell & Maran's textbook of head and neck surgery and oncology,” in Lip and Oral Cavity Cancer, p. 549, CRC Press, 2012. View at Google Scholar
  5. J. P. Shah and Z. Gil, “Current concepts in management of oral cancer—surgery,” Oral Oncology, vol. 45, no. 4-5, pp. 394–401, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. A. P. Jellema, B. J. Slotman, P. Doornaert, C. R. Leemans, and J. A. Langendijk, “Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer,” International Journal of Radiation Oncology, Biology, Physics, vol. 69, no. 3, pp. 751–760, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. J. P. Shah, R. A. Cendon, H. W. Farr, and E. W. Strong, “Carcinoma of the oral cavity. Factors affecting treatment failure at the primary site and neck,” The American Journal of Surgery, vol. 132, no. 4, pp. 504–507, 1976. View at Publisher · View at Google Scholar · View at Scopus
  8. A. S. Jones, Z. Bin Hanafi, V. Nadapalan, N. J. Roland, A. Kinsella, and T. R. Helliwell, “Do positive resection margins after ablative surgery for head and neck cancer adversely affect prognosis? A study of 352 patients with recurrent carcinoma following radiotherapy treated by salvage surgery,” British Journal of Cancer, vol. 74, no. 1, pp. 128–132, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. J. A. Woolgar and A. Triantafyllou, “A histopathological appraisal of surgical margins in oral and oropharyngeal cancer resection specimens,” Oral Oncology, vol. 41, no. 10, pp. 1034–1043, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. J. R. Jacobs, K. Ahmad, R. Casiano et al., “Implications of positive surgical margins,” The Laryngoscope, vol. 103, no. 1, pp. 64–68, 1993. View at Google Scholar · View at Scopus
  11. J. G. Lee, “Detection of residual carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx: a study of surgical margins,” Transactions of the American Academy of Ophthalmology and Otolaryngology, vol. 78, no. 1, pp. 49–53, 1974. View at Google Scholar · View at Scopus
  12. J. D. Meier, D. A. Oliver, and M. A. Varvares, “Surgical margin determination in head and neck oncology: current clinical practice. The results of an International American Head and Neck Society member survey,” Head & Neck, vol. 27, no. 11, pp. 952–958, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Helliwell and J. A. Woolgar, Standards and Minimum Datasets for Reporting cancers. Dataset for Histopathologic Reports on Head and Neck Carcinomas and Salivary Neoplasms, Royal College of Pathologists, London, UK, 2nd edition, 2005.
  14. K. G. Looser, J. P. Shah, and E. W. Strong, “The significance of “positive” margins in surgically resected epidermoid carcinomas,” Head & Neck Surgery, vol. 1, no. 2, pp. 107–111, 1978. View at Publisher · View at Google Scholar · View at Scopus
  15. T. R. Loree and E. W. Strong, “Significance of positive margins in oral cavity squamous carcinoma,” The American Journal of Surgery, vol. 160, no. 4, pp. 410–414, 1990. View at Publisher · View at Google Scholar · View at Scopus
  16. J. J. Pindborg and S. M. Sirsat, “Oral submucous fibrosis,” Oral Surgery, Oral Medicine, Oral Pathology, vol. 22, no. 6, pp. 764–779, 1966. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Chaturvedi, S. S. Vaishampayan, S. Nair et al., “Oral squamous cell carcinoma arising in background of oral submucous fibrosis: a clinicopathologically distinct disease,” Head & Neck, vol. 35, no. 10, pp. 1404–1409, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Anneroth, J. Batsakis, and M. Luna, “Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas,” Scandinavian Journal of Dental Research, vol. 95, no. 3, pp. 229–249, 1987. View at Google Scholar · View at Scopus
  19. R. W. Nason, A. Binahmed, K. A. Pathak, A. A. Abdoh, and G. K. B. Sándor, “What is the adequate margin of surgical resection in oral cancer?” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 107, no. 5, pp. 625–629, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Barrya, R. Shawa, J. Woolgarb, S. Rogersa, D. Lowea, and J. Browna, “OP081: evidence to support: a 3 mm margin as oncologically safe in early oral SCC,” Oral Oncology, vol. 49, supplement 1, S37 pages, 2013. View at Publisher · View at Google Scholar
  21. J. McMahon, C. J. O'Brien, I. Pathak et al., “Influence of condition of surgical margins on local recurrence and disease-specific survival in oral and oropharyngeal cancer,” British Journal of Oral and Maxillofacial Surgery, vol. 41, no. 4, pp. 224–231, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. J. G. Batsakis, “Surgical excision margins: A pathologist's perspective,” Advances in Anatomic Pathology, vol. 6, no. 3, pp. 140–148, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. R. E. Johnson, J. D. Sigman, G. F. Funk, R. A. Robinson, and H. T. Hoffman, “Quantification of surgical margin shrinkage in the oral cavity,” Head and Neck, vol. 19, no. 4, pp. 281–286, 1997. View at Publisher · View at Google Scholar · View at Scopus
  24. R. C. Mistry, S. S. Qureshi, and C. Kumaran, “Post-resection mucosal margin shrinkage in oral cancer: quantification and significance,” Journal of Surgical Oncology, vol. 91, no. 2, pp. 131–133, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. D. González Ballester, I. Rubio Correa, C. Hernández Vila et al., “OP082: effect of the tissue shrinkage phenomenon on surgical margins of resection in patients undergoing cancer oral and oropharynx,” Oral Oncology, vol. 49, p. S37, 2013. View at Google Scholar
  26. M. Alicandri-Ciufelli, M. Bonali, A. Piccinini et al., “Surgical margins in head and neck squamous cell carcinoma: What is “close”?” European Archives of Oto-Rhino-Laryngology, vol. 270, no. 10, pp. 2603–2609, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. J. D. Meier, D. A. Oliver, and M. A. Varvares, “Surgical margin determination in head and neck oncology: current clinical practice. The results of an International American Head and Neck Society member survey,” Head and Neck, vol. 27, no. 11, pp. 952–958, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. J. S. Cooper, K. Fu, J. Marks, and S. Silverman, “Late effects of radiation therapy in the head and neck region,” International Journal of Radiation Oncology, Biology, Physics, vol. 31, no. 5, pp. 1141–1164, 1995. View at Publisher · View at Google Scholar · View at Scopus
  29. D. P. Slaughter, H. W. Southwick, and W. Smejkal, “‘Field cancerization’ in oral stratified squamous epithelium. Clinical implications of multicentric origin,” Cancer, vol. 6, no. 5, pp. 963–968, 1953. View at Publisher · View at Google Scholar · View at Scopus
  30. L. S. Wong, J. McMahon, J. Devine et al., “Influence of close resection margins on local recurrence and disease-specific survival in oral and oropharyngeal carcinoma,” British Journal of Oral and Maxillofacial Surgery, vol. 50, no. 2, pp. 102–108, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Ch'ng, S. Corbett-Burns, N. Stanton et al., “Close margin alone does not warrant postoperative adjuvant radiotherapy in oral squamous cell carcinoma,” Cancer, vol. 119, no. 13, pp. 2427–2437, 2013. View at Publisher · View at Google Scholar · View at Scopus