International Journal of Surgical Oncology / 2015 / Article / Tab 2

Review Article

Gastrectomy and D2 Lymphadenectomy for Gastric Cancer: A Meta-Analysis Comparing the Harmonic Scalpel to Conventional Techniques

Table 2

Study and baseline characteristics for studies meeting inclusion criteria.

ReferenceCountryInterventionAge (mean ± SD)% male SurgeryStudy length (months)Included endpoints

Choi et al., 2014 [21]KoreaHarmonic scalpel
Monopolar electric coagulator and clips
128  
125
52.8 ± 10.7  
53.9 ± 10.5 
60.9%  
64.8%
Gastrectomy with D2 lymph node dissection16 (i) Operating time  
(ii) Intraoperative blood loss  
 (iii) Postoperative lymphatic drainage  
(iv) Postoperative complication

Chen, 2012 [20]ChinaHarmonic scalpel (GEN300)  
Conventional techniques (knot-tying)
60  
60
58.9 ± 19.365.0%Distal radical resection of gastric carcinoma and lymphadenectomy25 (i) Operation time  
(ii) Intraoperative blood loss  
(iii) Drainage volume

Cui et al., 2012 [31]ChinaHarmonic scalpel (GEN300)  
Electrosurgery
31  
31
56.4 ± 9.9  
58.9 ± 9.2
67.7%  
58.1%
Gastrectomy with D2 lymph node dissection48 (i) Operation time  
(ii) Blood loss volume  
(iii) Postoperative drainage volume of the first 72 hours  
(iv) Length of postoperative hospital stay  
(v) Complication rate

Inoue et al., 2012 [26]JapanHarmonic Focus  
Electrosurgery and knot-tying
30  
30
64 (41–79)
67 (45–92)
70.0%  
73.3%
Gastrectomy with lymph node dissections (combined resection performed in 6 patients in each group)11(i) Operative time  
(ii) Blood loss  
(iii) Postoperative drainage volume  
(iv) Postoperative hospital stay  
(v) Surgery-related complications  
(vi) Number of transfused patients

Liu et al., 2010 [29]ChinaHarmonic scalpel (GEN300)  
Electrosurgery
19  
21
62  
64
63.2%  
57.1%
Radical distal resection of gastric carcinoma with D2 dissection29 (i) Operation time  
(ii) Blood loss  
(iii) Peritoneal drainage volume of the first 3 days

Lu et al., 2008 [24]ChinaHarmonic scalpel (GEN300)  
Monopolar electrosurgery
26  
23

61.5%  
56.5%
Distal radical gastrectomy with D2 dissection11 (i) Length of operating time for lymphadenectomy  
(ii) Blood loss in lymphadenectomy  
(iii) Drainage volume

Tsimoyiannis et al., 2002 [28]GreeceHarmonic scalpel  
Monopolar electrosurgery
20  
20
59 ± 10  
62 ± 9
80%  
75%
Gastrectomy with D2 dissection24 (i) Operative time  
(ii) Operative blood loss  
(iii) Postoperative abdominal drainage  
(iv) Number of patients transfused  
(v) Postoperative hospital stay  
(vi) Frequency of major complication

Wang et al., 2010 [30]ChinaHarmonic scalpel (GEN300)  
Monopolar electrosurgery
38  
30
61.8 ± 21.560.30%Laparoscopic radical distal D2 gastrectomy23 (i) Operation time  
(ii) Intraoperative bleeding volume  
(iii) Postsurgery 3-day drainage volume

Wilhelm et al.,
2011 [23]
GermanyHarmonic Wave Ultrasound Dissector  
Electrocautery, sutures, and ligatures
100  
101
66 ± 12  
64 ± 12
60%  
61.40%
Left hemicolectomy and gastrectomy with D2 lymphadenectomy24 (i) Duration of operation  
(ii) Perioperative blood loss  
(iii) Intraoperative complications  
(iv) Duration of hospital stay

Xu et al., 2010 [32]ChinaHarmonic scalpel  
Electrosurgery and knot-tying
23  
19
61  
64
60.90%  
63.20%
Distal radical gastrectomy with D2 dissection18 (i) Operation time  
(ii) Intraoperative blood loss  
(iii) Postoperative drainage volume

Age reported as median (range).
Reported outcomes that included only lymphadenectomy patients were excluded from the analysis.
Reported outcomes that included patients who received hemicolectomy were excluded from the analysis.

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