Clinical Study

Neoadjuvant Chemotherapy in Locally Advanced and Borderline Resectable Nonsquamous Sinonasal Tumors (Esthesioneuroblastoma and Sinonasal Tumor with Neuroendocrine Differentiation)

Table 5

Factors affecting achievement of resectability.

Presence of factor Resectability achieved value on Fisher’s test
(one sided)
value on binary logistic regression analysis

Anatomical factors
Intracranial extension up to extradural regionYes: 148 0.430 Not included
No: 1105
Intradural intracranial extension but brain parenchyma uninvolvedYes: 1006 0.404 Not included
No: 1507
Intradural extension with brain parenchyma involvementYes: 0503 0.541 Not included
No: 2010
Involvement of orbitYes: 1307 0.582 Not included
No: 1206
Involvement of infratemporal fossaYes: 0602 0.281 0.851
No: 1911
Involvement of parapharyngeal spaceYes: 0201 0.741 Not included
No: 2312
Surgical pre-NACT statusUnresectable: 1101 0.000 0.003
Resectable: 1412

Biological factors
PathologyE: 1208 0.157 Not included
SNE: 1305
ResponseCR + PR: 2012 0.136 0.139
SD + PD: 0501