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PMID | First author | Country | Publication year | RCT type | POPF definition |
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26135690 | Keck | Germany | 2016 | Multicenter, randomized, controlled, observer- and patient-blinded trial | ISGPS (grade B/C) |
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25799130 | Grendar | Canada | 2015 | Single-center, randomized, controlled trial | Radiologically proven anastomotic leak or continued drainage of lipase-rich fluid on PoD 10. Classification by ISGPS |
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24467711 | El Nakeeb | Egypt | 2014 | Single-center, prospective, randomized study | ISGPS (grade A/B/C) |
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24264781 | Figueras | Spain | 2013 | Multicenter, prospective, randomized study | ISGPS (grade B/C) |
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23643139 | Topal | Belgium | 2013 | Multicenter, randomised, superiority trial | ISGPS (grade B/C) |
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22744638 | Wellner | Germany | 2012 | Single-center, open, randomized, controlled study | ISGPS (grade B/C) |
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19092337 | Fernàndez-Cruz | Spain | 2008 | Single-center, prospective, randomized study | ISGPS (grade B/C) |
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16327486 | Bassi | Italy | 2005 | Single-center, prospective, randomized study | Any clinical significant output of fluid, rich in amylase, confirmed by fistulography |
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15910726 | Duffas | France | 2005 | Multicenter, single blind, controlled, randomized trial | Fluid obtained through drains or percutaneous aspiration, containing at least 4 times normal serum values of amylase for 3 days or as anastomotic leaks shown by fistulography |
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7574936 | Yeo | USA | 1995 | Single-center, prospective, randomized trial | Drainage of greater than 50 mL of amylase rich fluid (greater than threefold elevation above upper limit of normal in serum) through the operatively placed drains on or after |
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