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International Journal of Surgical Oncology
Volume 2018, Article ID 4547892, 4 pages
Research Article

Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature

Department of Medical Oncology, Salah Azaïz Institute, Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia

Correspondence should be addressed to Manel Dridi; moc.liamg@78lenamidird

Received 9 February 2017; Revised 18 June 2017; Accepted 13 September 2017; Published 29 March 2018

Academic Editor: Anil D’cruz

Copyright © 2018 Manel Dridi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Adult granulosa cell tumors (AGCTs) are the most common sex cord-stromal tumors. Unlike epithelial ovarian tumors, they occur in young women and are usually detected at an early stage. The aim of this study was to report the clinical and pathological characteristics of AGCT patients and to identify the prognostic factors. Methods. All cases of AGCTs, treated at Salah Azaïz Institute between 1995 and 2010, were retrospectively included. Kaplan-Meier’s statistical method was used to assess the relapse-free survival and the overall survival. Results. The final cohort included 31 patients with AGCT. The mean age was 53 years (35–73 years). Patients mainly presented with abdominal mass and/or pain (61%, ). Mean tumor size was 20 cm. The majority of patients had a stage I disease (61%,  ). Two among 3 patients with stage IV disease had liver metastasis. Mitotic index was low in 45% of cases (). Surgical treatment was optimal in almost all cases (90%, ). The median follow-up time was 14 years (1–184 months). Ten patients relapsed (32%) with a median RFS of 8.4 years (6.8–9.9 years). Mean overall survival was 13 years (11–15 years). Stage I disease and low-to-intermediate mitotic index were associated with a better prognosis in univariate analysis (resp., and ) but were not independent prognostic factors. Conclusion. GCTs have a long natural history with common late relapses. Hence, long active follow-up is recommended. In Tunisian patients, hepatic metastases were more frequent than occidental series. The prognosis remains good and initial staging at diagnosis is an important prognostic factor.