Research Article
Survival Benefit of Intervention Treatment in Advanced Anaplastic Thyroid Cancer
Table 2
Unadjusted univariable Cox proportional hazard model of prognostic factors.
| Variable | Hazard ratio (95% CI) | value |
| Age (years) | | | <65 | Reference | 0.022 | ≥65 | 1.6 (1.1–2.0) | |
| Treatment | | | Intervention | Reference | 0.001 | Palliative | 2.0 (1.3–3.0) | |
| Staging | | | 4a | Reference | | 4b | 0.95 (0.7–1.7) | 0.819 | 4c | 1.35 (0.92–2.27) | 0.221 |
| Thyroid function test | | | Euthyroid | Reference | | Hypothyroid | 4.50 (1.19–13.57) | 0.008 | Hyperthyroid | 3.75 (0.93–15.07) | 0.063 |
| White blood cell (cells/ml3) | | | <10000 | Reference | | ≥10000 | 2.05 (1.25–3.35) | 0.004 |
| Underlying disease | | | Absent | Reference | | Present | 1.19 (0.79–1.81) | 0.403 |
| Tumor size (cm) | | | <5 | Reference | | ≥5 | 2.32 (0.84–6.38) | 0.104 |
| Extrathyroid extension | | | No | Reference | | Yes | 1.12 (0.75–1.69) | 0.569 |
| Cervical lymph node metastasis | | | No | Reference | | Unilateral single | 1.03 (0.64–1.65) | 0.914 | Unilateral multiple | 0.76 (0.44–1.31) | 0.328 | Bilateral | 1.41 (0.71–2.77) | 0.323 |
| Distance metastasis | | | No | Reference | | Present (lung, bone, and liver) | 1.33 | 0.183 |
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